InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IDI1

Summary

InnateDB Gene

IDBG-639612.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDI1

Gene Name

Isopentenyl-diphosphate Delta-isomerase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004075

Encoded Proteins

IDBP-691791

Isopentenyl-diphosphate Delta-isomerase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26938778

[Mus musculus] Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067064:
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:46682710-46685834

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005323

ENSBTAP00000005323

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004452	isopentenyl-diphosphate delta-isomerase activity
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0035634	response to stilbenoid
GO:0050992	dimethylallyl diphosphate biosynthetic process