Version 5.4
Bos taurus Gene: NCF1
Summary
InnateDB Gene IDBG-639883.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCF1
Gene Name Neutrophil cytosol factor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003305
Encoded Proteins
IDBP-692080
Neutrophil cytosol factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158517:
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:33267458-33282335
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004279 ENSBTAP00000004279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0017124 SH3 domain binding
GO:0035091 phosphatidylinositol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001878 response to yeast
GO:0001909 leukocyte mediated cytotoxicity
GO:0002679 respiratory burst involved in defense response
GO:0006612 protein targeting to membrane
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0008283 cell proliferation
GO:0009617 response to bacterium
GO:0042554 superoxide anion generation
GO:0042742 defense response to bacterium
GO:0045730 respiratory burst
GO:0045986 negative regulation of smooth muscle contraction
GO:0050665 hydrogen peroxide biosynthetic process
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0055114 oxidation-reduction process
GO:0070946 neutrophil mediated killing of gram-positive bacterium
GO:0070947 neutrophil mediated killing of fungus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0043020 NADPH oxidase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158517
View Gene Order
ENSMUSG00000015950
View Gene Order
Pathways
NETPATH
REACTOME
REACT_220738
Phagosomal maturation (early endosomal stage) pathway
REACT_218962
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_213138
Immune System pathway
REACT_202485
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_214353
Signal Transduction pathway
REACT_226693
Signaling by VEGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_207087
Disease pathway
REACT_218645
Antigen processing-Cross presentation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_121256
Phagosomal maturation (early endosomal stage) pathway
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_121237
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_116125
Disease pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_189085
Disease pathway
REACT_227951
Signaling by VEGF pathway
REACT_198345
Phagosomal maturation (early endosomal stage) pathway
REACT_198347
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
REACT_230745
Immune System pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_199093
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05140
Leishmaniasis pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu05140
Leishmaniasis pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
PID NCI
rac1_pathway
RAC1 signaling pathway
Cross-References
SwissProt O77774
TrEMBL
UniProt Splice Variant
Entrez Gene 281345
UniGene Bt.142
RefSeq NM_174119
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF079302 BC103145 BT020852 BT021181
GenPept AAC82462 AAI03146 AAX08869 AAX31363
RNA Seq Atlas 281345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca