Bos taurus Gene: LIMK1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-639960.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | LIMK1 | ||||||||||||||||||||||
Gene Name | LIM domain kinase 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000044083 | ||||||||||||||||||||||
Encoded Proteins |
LIM domain kinase 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106683:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 25:33750878-33775707 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
Leptin pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Sema4D induced cell migration and growth-cone collapse pathway
Sema4D in semaphorin signaling pathway
Sema3A PAK dependent Axon repulsion pathway
Developmental Biology pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Sema3A PAK dependent Axon repulsion pathway
Immune System pathway
Sema4D induced cell migration and growth-cone collapse pathway
EPH-Ephrin signaling pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Sema4D in semaphorin signaling pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Developmental Biology pathway
Semaphorin interactions pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Axon guidance pathway
Fc gamma R-mediated phagocytosis pathway
Axon guidance pathway
Regulation of actin cytoskeleton pathway
Fc gamma R-mediated phagocytosis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Caspase Cascade in Apoptosis
CXCR4-mediated signaling events
RAC1 signaling pathway
CDC42 signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | E1BC64 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 535225 | ||||||||||||||||||||||
UniGene | Bt.62771 | ||||||||||||||||||||||
RefSeq | NM_001206904 XM_005225179 | ||||||||||||||||||||||
HUGO | HGNC:6613 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | DAAA02058194 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 535225 | ||||||||||||||||||||||
Transcript Frequencies | |||||||||||||||||||||||
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).
Based on Data from Bovine Gene Atlas |
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