InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SAE1

Summary

InnateDB Gene

IDBG-639978.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAE1

Gene Name

SUMO-activating enzyme subunit 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002676

Encoded Proteins

IDBP-692178

SUMO-activating enzyme subunit 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142230:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:54608486-54670718

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003467

ENSBTAP00000003467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0019948	SUMO activating enzyme activity
GO:0043008	ATP-dependent protein binding

Biological Process

GO:0006464	cellular protein modification process
GO:0007346	regulation of mitotic cell cycle
GO:0016925	protein sumoylation
GO:0019950	SMT3-dependent protein catabolic process