Version 5.4
Bos taurus Gene: RAD54L
Summary
InnateDB Gene IDBG-639983.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD54L
Gene Name DNA repair and recombination protein RAD54-like
Synonyms RAD54-like
Species Bos taurus
Ensembl Gene ENSBTAG00000019901
Encoded Proteins
IDBP-692184
DNA repair and recombination protein RAD54-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085999:
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:100419939-100445702
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026513 ENSBTAP00000026513
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0036310 annealing helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000733 DNA strand renaturation
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
GO:0042493 response to drug
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085999
View Gene Order
ENSMUSG00000028702
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
mmu03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A1L4Z4
UniProt Splice Variant
Entrez Gene 100140639
UniGene Bt.106758
RefSeq NM_001130766
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT029781 DAAA02009002
GenPept ABM06051
RNA Seq Atlas 100140639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca