InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRDX1

Summary

InnateDB Gene

IDBG-640075.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX1

Gene Name

Peroxiredoxin-1

Synonyms

PRX1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003642

Encoded Proteins

IDBP-692290

Peroxiredoxin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117450:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:101152892-101166725

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004751

ENSBTAP00000004751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0051920	peroxiredoxin activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001895	retina homeostasis
GO:0006979	response to oxidative stress
GO:0008283	cell proliferation
GO:0019430	removal of superoxide radicals
GO:0032872	regulation of stress-activated MAPK cascade
GO:0034101	erythrocyte homeostasis
GO:0042267	natural killer cell mediated cytotoxicity
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process