InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MDH2

Summary

InnateDB Gene

IDBG-640116.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDH2

Gene Name

malate dehydrogenase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009462

Encoded Proteins

IDBP-692350

malate dehydrogenase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146701:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq, Jul 2008]
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:34766932-34779637

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012454

ENSBTAP00000012454

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0016491	oxidoreductase activity
GO:0016615	malate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060	L-malate dehydrogenase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006099	tricarboxylic acid cycle
GO:0006108	malate metabolic process
GO:0006475	internal protein amino acid acetylation
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process