Version 5.4
Bos taurus Gene: AVP
Summary
InnateDB Gene IDBG-640134.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AVP
Gene Name Vasopressin-neurophysin 2-copeptin Arg-vasopressin Neurophysin 2 Copeptin
Synonyms AVP-NPII
Species Bos taurus
Ensembl Gene ENSBTAG00000008027
Encoded Proteins
IDBP-692354
Vasopressin-neurophysin 2-copeptinArg-vasopressinNeurophysin 2Copeptin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21615666
[Homo sapiens] AVP regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.
PMID 21615666
[Mus musculus] Avp regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101200:
This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:52563657-52565676
Strand Forward strand
Band
Transcripts
ENSBTAT00000010555 ENSBTAP00000010555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004871 signal transducer activity
GO:0005179 hormone activity
GO:0005185 neurohypophyseal hormone activity
GO:0031894 V1A vasopressin receptor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010628 positive regulation of gene expression
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042310 vasoconstriction
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050880 regulation of blood vessel size
GO:0070371 ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0090201 negative regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101200
View Gene Order
ENSMUSG00000037727
View Gene Order
Pathways
NETPATH
REACTOME
REACT_216552
Aquaporin-mediated transport pathway
REACT_202137
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_204802
Vasopressin-like receptors pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_216574
Transport of organic anions pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_218813
Transport of vitamins, nucleosides, and related molecules pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_210271
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_227144
Circadian Clock pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_23988
Transport of organic anions pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_17041
Vasopressin-like receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_115781
Bmal1:Clock,Npas2 activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_259014
Vasopressin-like receptors pathway
REACT_200794
Mus musculus biological processes pathway
REACT_223625
GPCR downstream signaling pathway
REACT_241925
Circadian Clock pathway
REACT_254215
Signaling by GPCR pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_232951
Transport of vitamins, nucleosides, and related molecules pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_226335
Aquaporin-mediated transport pathway
REACT_213947
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_210189
Transport of organic anions pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
mmu04962
Vasopressin-regulated water reabsorption pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.106073 Bt.49210
RefSeq NM_176854
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca