Version 5.4
| Bos taurus Gene: STAT3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-640197.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | STAT3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | signal transducer and activator of transcription 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000021523 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
signal transducer and activator of transcription 3
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] STAT3 is a transcription factor that mediates interleukin-10 (IL-10) cytokine signalling.
[Homo sapiens] STAT3 and SRC have a role in the immunoregulation of dendritic cells (DCs) where apoptotic cells-induced inhibition of dendritic cells (DCs) requires MerTK-dependent activation of SRC and STAT3.
[Homo sapiens] STAT3 mediates mucosa-protective and anti-inflammatory functions in epithelial and myeloid cells and promotes inflammation in T cells.
[Homo sapiens] STAT3 binds to multiple genes involved in Th17 cell differentiation, cell activation, proliferation, and survival, regulating both expression, epigenetic modifications, and targets the T cell function in inflammation and homeostasis.
[Homo sapiens] STAT3 is an essential mediator of emergency granulopoiesis via its regulation of transcription factors CEBPA and CEBPB that direct granulocyte colony-stimulating factor (G-CSF)-responsive myeloid progenitor expansion.
[Homo sapiens] STAT3 is a negative regulator of type I IFN-mediated anti-viral responses. (Demonstrated in mouse)
[Homo sapiens] In alveolar epithelium, IL22 upregulates DEFB4A gene expression via STAT3.
[Homo sapiens] MIR29A inhibits IL10-induced cytokine release by targeting JAK-STAT3 in monocytes during sepsis.
[Mus musculus] Stat3 is a negative regulator of type I IFN-mediated anti-viral responses.
[Mus musculus] STAT3 mediates protein transport and secretion in hepatocytes during the acute phase of pneumonia.
[Mus musculus] Stat3 mediates protection against intestinal infection by inducing innate lymphoid cell derived-Il22.
[Mus musculus] Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168610:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 19:43056660-43132624 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 289 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSH pathway
TSLP pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
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| REACTOME |
Growth hormone receptor signaling pathway
Interleukin-6 signaling pathway
Signalling to STAT3 pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signaling by FGFR1 fusion mutants pathway
Signaling by FGFR mutants pathway
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Developmental Biology pathway
Signalling by NGF pathway
Transcriptional regulation of pluripotent stem cells pathway
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
Cytokine Signaling in Immune system pathway
Signaling by FGFR1 mutants pathway
Signal Transduction pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
NGF signalling via TRKA from the plasma membrane pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Disease pathway
Signaling by Leptin pathway
Mus musculus biological processes pathway
Disease pathway
Signaling by Leptin pathway
Signaling by FGFR in disease pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Downstream signal transduction pathway
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
Transcriptional regulation of pluripotent stem cells pathway
Signalling to STAT3 pathway
Signaling by Interleukins pathway
Interleukin-6 signaling pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Signalling by NGF pathway
Signaling by PDGF pathway
Developmental Biology pathway
Signaling by FGFR1 fusion mutants pathway
NGF signalling via TRKA from the plasma membrane pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
Signaling by Leptin pathway
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| KEGG |
Acute myeloid leukemia pathway
Jak-STAT signaling pathway pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Toxoplasmosis pathway
Hepatitis C pathway
Jak-STAT signaling pathway pathway
Acute myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Toxoplasmosis pathway
Hepatitis C pathway
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| INOH |
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
IL-6 signaling pathway
LIF signaling pathway
TPO signaling pathway
IL-23 signaling pathway
IFN alpha signaling pathway
IL-10 signaling pathway
BMP2 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
IL-6 signaling pathway
LIF signaling pathway
TPO signaling pathway
BMP2 signaling pathway
IL-23 signaling pathway
IFN alpha signaling pathway
IL-10 signaling pathway
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| PID NCI |
IL2-mediated signaling events
IL27-mediated signaling events
IL12-mediated signaling events
Signaling events mediated by PTP1B
ErbB1 downstream signaling
IL12 signaling mediated by STAT4
Signaling events mediated by HDAC Class I
Notch-mediated HES/HEY network
Neurotrophic factor-mediated Trk receptor signaling
RAC1 signaling pathway
FGF signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
IL23-mediated signaling events
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
IL6-mediated signaling events
IFN-gamma pathway
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.15334 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001012671 XM_005220691 XM_005220693 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||