InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTRF

Summary

InnateDB Gene

IDBG-640215.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTRF

Gene Name

polymerase I and transcript release factor isoform 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039684

Encoded Proteins

IDBP-692443

polymerase I and transcript release factor isoform 2

IDBP-692445

polymerase I and transcript release factor isoform 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177469:
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43148013-43162165

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061251	ENSBTAP00000053553
ENSBTAT00000055460	ENSBTAP00000050255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042134	rRNA primary transcript binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex