InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCNT

Summary

InnateDB Gene

IDBG-640315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCNT

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030670

Encoded Proteins

IDBP-692628

pericentrin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160299:
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:147736441-147840896

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029328

ENSBTAP00000029328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001701	in utero embryonic development
GO:0001764	neuron migration
GO:0007051	spindle organization
GO:0021696	cerebellar cortex morphogenesis
GO:0021772	olfactory bulb development
GO:0035108	limb morphogenesis
GO:0035264	multicellular organism growth
GO:0042384	cilium assembly
GO:0043066	negative regulation of apoptotic process
GO:0048854	brain morphogenesis
GO:0061351	neural precursor cell proliferation
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005815	microtubule organizing center
GO:0016020	membrane
GO:0031514	motile cilium
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0045171	intercellular bridge