Bos taurus Gene: GPSM1 | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-640436.3 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | GPSM1 | ||||||||
Gene Name | Uncharacterized protein | ||||||||
Synonyms | |||||||||
Species | Bos taurus | ||||||||
Ensembl Gene | ENSBTAG00000018799 | ||||||||
Encoded Proteins |
G-protein signaling modulator 1
G-protein signaling modulator 1
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
InnateDB Annotation from Orthologs | |||||||||
Summary |
[Homo sapiens] GPSM1, an inhibitor of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1, and CCDC88A determines whether autophagy is promoted or inhibited. During starving conditions, GPSM1 binds to GNAI3 in MAP1LC3A-positive membranes to promote autophagy. When stimulated by growth factors, CCDC88A promotes the dissociation of GPSM1::GNAI3 complex to initiate anti-autophagy signalling pathways.
[Mus musculus] Gpsm1, an inhibitor of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1, and Ccdc88a determines whether autophagy is promoted or inhibited. During starving conditions, Gpsm1 binds to Gnai3 in Map1lc3a-positive membranes to promote autophagy. When stimulated by growth factors, Ccdc88a promotes the dissociation of Gpsm1::Gnai3 complex to initiate anti-autophagy signaling pathways.
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Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160360:
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 11:103840005-103869617 | ||||||||
Strand | Forward strand | ||||||||
Band | |||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | |||||||||
UniGene | |||||||||
RefSeq | XM_002691658 XM_005213457 | ||||||||
HUGO | |||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | |||||||||
GenPept | |||||||||
RNA Seq Atlas | |||||||||