Version 5.4
| Bos taurus Gene: DKK2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-640587.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | DKK2 | ||||||||
| Gene Name | dickkopf-related protein 2 precursor | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000012969 | ||||||||
| Encoded Proteins |
dickkopf-related protein 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155011:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 6:19381413-19511148 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
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| KEGG |
Wnt signaling pathway pathway
Wnt signaling pathway pathway
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| INOH |
Wnt signaling pathway pathway
Wnt signaling pathway pathway
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| PID NCI |
Presenilin action in Notch and Wnt signaling
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | A3KMY2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 541161 | ||||||||
| UniGene | Bt.24868 | ||||||||
| RefSeq | NM_001082615 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC133394 DAAA02016640 DAAA02016641 DAAA02016642 | ||||||||
| GenPept | AAI33395 | ||||||||
| RNA Seq Atlas | 541161 | ||||||||