InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DLX1

Summary

InnateDB Gene

IDBG-640636.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLX1

Gene Name

homeobox protein DLX-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015217

Encoded Proteins

IDBP-692916

distal-less homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144355:
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:24502929-24506672

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020246

ENSBTAP00000020246

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043524	negative regulation of neuron apoptotic process
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000144355

View Gene Order

ENSMUSG00000041911

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.87150

RefSeq

NM_001099017

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas