InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTPS

Summary

InnateDB Gene

IDBG-640673.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTPS

Gene Name

CTP synthase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001626

Encoded Proteins

IDBP-692960

CTP synthase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171793:
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:105800997-105832415

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002131

ENSBTAP00000002131

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003883	CTP synthase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016874	ligase activity

Biological Process

GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0006541	glutamine metabolic process
GO:0044210	'de novo' CTP biosynthetic process