Bos taurus Gene: TIGAR | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-640708.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | TIGAR | ||||||||||||||||
Gene Name | Fructose-2,6-bisphosphatase TIGAR | ||||||||||||||||
Synonyms | TIGAR | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000016650 | ||||||||||||||||
Encoded Proteins |
Probable fructose-2,6-bisphosphatase TIGAR
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078237:
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 5:106223071-106238040 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME | |||||||||||||||||
KEGG |
Fructose and mannose metabolism pathway
Fructose and mannose metabolism pathway
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INOH | |||||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | Bt.61374 | ||||||||||||||||
RefSeq | NM_001076370 XM_005207193 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | |||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||