Version 5.4
Bos taurus Gene: DAZL
Summary
InnateDB Gene IDBG-640772.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAZL
Gene Name deleted in azoospermia-like
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000502
Encoded Proteins
IDBP-693065
deleted in azoospermia-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092345:
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155383458-155406442
Strand Reverse strand
Band
Transcripts
ENSBTAT00000048665 ENSBTAP00000045661
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0008494 translation activator activity
GO:0042802 identical protein binding
Biological Process
GO:0001556 oocyte maturation
GO:0007147 female meiosis II
GO:0007281 germ cell development
GO:0045836 positive regulation of meiosis
GO:0045948 positive regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000092345
View Gene Order
ENSMUSG00000010592
View Gene Order
Cross-References
SwissProt
TrEMBL A3DUJ0
UniProt Splice Variant
Entrez Gene 530116
UniGene Bt.63695
RefSeq NM_001081725
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003725 DQ408764 DQ408765 EF501823
GenPept ABD73127 ABD73128 ABS57164
RNA Seq Atlas 530116

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca