Bos taurus Gene: SMURF1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-640859.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | SMURF1 | ||||||||||||||||||||||||
Gene Name | E3 ubiquitin-protein ligase | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000007118 | ||||||||||||||||||||||||
Encoded Proteins |
SMAD specific E3 ubiquitin protein ligase 1
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198742:
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 25:37777779-37801407 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 279 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
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REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Signaling by BMP pathway
PCP/CE pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Asymmetric localization of PCP proteins pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by Wnt pathway
Loss of Function of SMAD4 in Cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by BMP pathway
TGFBR1 LBD Mutants in Cancer pathway
Immune System pathway
TGF-beta receptor signaling activates SMADs pathway
Loss of Function of TGFBR2 in Cancer pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
PCP/CE pathway pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Adaptive Immune System pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Asymmetric localization of PCP proteins pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
TGF-beta signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
Ubiquitin mediated proteolysis pathway
TGF-beta signaling pathway pathway
Endocytosis pathway
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INOH |
TGF-beta signaling pathway
TGF-beta signaling pathway
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PID NCI |
BMP receptor signaling
Signaling events mediated by HDAC Class I
TGF-beta receptor signaling
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Bt.110349 | ||||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||