Version 5.4
| Homo sapiens Gene: IL1R1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-64088.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | IL1R1 | ||||||||||||||||||||||
| Gene Name | interleukin 1 receptor, type I | ||||||||||||||||||||||
| Synonyms | CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80 | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000115594 | ||||||||||||||||||||||
| Encoded Proteins |
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
interleukin 1 receptor, type I
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||
| Summary |
IL1R1 is a substrate for presenilin-dependent gamma-secretase cleavage and intramembrane proteolysis may be a control mechanism for IL1R1-mediated signalling.
IL1R1 is essential for TLR9-dependent activation of tumour necrosis factor receptor-associated factor 3 (TRAF3) and for production of the anti-inflammatory cytokines IL-10 and type I interferon (IFN).
IL1R1 is the primary receptor for the inflammatory cytokine IL1B.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Mus musculus] Il1r1 is the primary receptor for the inflammatory cytokine Il1b. (Demonstrated in human)
[Mus musculus] IL1R1 upregulates Mir135b as a negative feedback regulatory mechanism to resolve cigarette smoke-induced inflammation in the lung.
[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008] This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 2:102064544-102179874 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q11.2 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH |
IL1 pathway
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| REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
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| KEGG |
Hematopoietic cell lineage pathway
Apoptosis pathway
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Amoebiasis pathway
Osteoclast differentiation pathway
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| INOH |
IL-1 signaling pathway pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
IL1-mediated signaling events
IL12-mediated signaling events
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Hs.701982 Hs.710940 | ||||||||||||||||||||||
| RefSeq | NM_000877 NM_001288706 XM_005263929 XM_005263930 XM_005263931 XM_005263932 XM_005263933 XM_005263934 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS2055 CCDS74547 | ||||||||||||||||||||||
| HPRD | 00994 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||