Version 5.4
Bos taurus Gene: RAC1
Summary
InnateDB Gene IDBG-641023.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC1
Gene Name Ras-related C3 botulinum toxin substrate 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009233
Encoded Proteins
IDBP-693334
Ras-related C3 botulinum toxin substrate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 25:38832485-38841319
Strand Forward strand
Band
Transcripts
ENSBTAT00000012170 ENSBTAP00000012170
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019899 enzyme binding
GO:0030742 GTP-dependent protein binding
GO:0031996 thioesterase binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002093 auditory receptor cell morphogenesis
GO:0003382 epithelial cell morphogenesis
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006972 hyperosmotic response
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0010592 positive regulation of lamellipodium assembly
GO:0015031 protein transport
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030334 regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031529 ruffle organization
GO:0032707 negative regulation of interleukin-23 production
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 engulfment of apoptotic cell
GO:0045216 cell-cell junction organization
GO:0048532 anatomical structure arrangement
GO:0048813 dendrite morphogenesis
GO:0048870 cell motility
GO:0051668 localization within membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060263 regulation of respiratory burst
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0072659 protein localization to plasma membrane
GO:0090103 cochlea morphogenesis
GO:0097178 ruffle assembly
Cellular Component
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0019897 extrinsic component of plasma membrane
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_212636
Signaling by Wnt pathway
REACT_211252
Sema4D in semaphorin signaling pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_217622
Activation of Rac pathway
REACT_215067
Factors involved in megakaryocyte development and platelet production pathway
REACT_205369
Signaling by GPCR pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_225483
CD28 dependent Vav1 pathway pathway
REACT_217565
Inactivation of Cdc42 and Rac pathway
REACT_216118
DCC mediated attractive signaling pathway
REACT_215526
L1CAM interactions pathway
REACT_218808
Sema4D induced cell migration and growth-cone collapse pathway
REACT_219722
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_205744
Netrin-1 signaling pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_211402
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_216684
Signal transduction by L1 pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_224780
CD28 co-stimulation pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_219098
GPVI-mediated activation cascade pathway
REACT_206475
Cell-Cell communication pathway
REACT_220724
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_249477
Ephrin signaling pathway
REACT_203140
Axon guidance pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_208369
NRAGE signals death through JNK pathway
REACT_207926
PCP/CE pathway pathway
REACT_214436
GPCR downstream signaling pathway
REACT_246661
EPH-ephrin mediated repulsion of cells pathway
REACT_207068
DSCAM interactions pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_205384
G alpha (12/13) signalling events pathway
REACT_214469
Adaptive Immune System pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_202074
FCERI mediated MAPK activation pathway
REACT_214988
DAP12 signaling pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
REACT_205196
Sema3A PAK dependent Axon repulsion pathway
REACT_213260
Membrane Trafficking pathway
REACT_203878
Signaling by Robo receptor pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P62998
TrEMBL F1MNG3
UniProt Splice Variant
Entrez Gene 281440
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF175262 BC103061 DAAA02058341
GenPept AAF00714 AAI03062
RNA Seq Atlas 281440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca