InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GFAP

Summary

InnateDB Gene

IDBG-641035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFAP

Gene Name

Glial fibrillary acidic protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013534

Encoded Proteins

IDBP-693351

Glial fibrillary acidic protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131095:
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:45241325-45250609

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017997

ENSBTAP00000017997

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0010625	positive regulation of Schwann cell proliferation
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0030198	extracellular matrix organization
GO:0031102	neuron projection regeneration
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0051580	regulation of neurotransmitter uptake
GO:0060020	Bergmann glial cell differentiation
GO:0060291	long-term synaptic potentiation