InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.99915

Summary

InnateDB Gene

IDBG-641113.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.99915

Gene Name

sodium channel protein type 2 subunit alpha

Synonyms

SCN2A1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038180

Encoded Proteins

IDBP-693448

sodium channel protein type 2 subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136531:
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:30981157-31119776

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061380

ENSBTAP00000053208

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007399	nervous system development
GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0051402	neuron apoptotic process
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0030424	axon
GO:0033270	paranode region of axon

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000136531

View Gene Order

ENSMUSG00000075318

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BMH1

UniProt Splice Variant

Entrez Gene

539718

UniGene

Bt.60666 Bt.99915

RefSeq

NM_001144109 XM_005202475

HUGO

HGNC:10588

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02004364

GenPept

RNA Seq Atlas

539718

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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