InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CACNA1C

Summary

InnateDB Gene

IDBG-641118.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1C

Gene Name

Uncharacterized protein

Synonyms

CAV1.2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010660

Encoded Proteins

IDBP-693586

calcium channel, voltage-dependent, L type, alpha 1C subunit

IDBP-693593

calcium channel, voltage-dependent, L type, alpha 1C subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151067:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:109152548-109417890

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014104	ENSBTAP00000014104
ENSBTAT00000063537	ENSBTAP00000056537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008331	high voltage-gated calcium channel activity
GO:0051393	alpha-actinin binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0007628	adult walking behavior
GO:0008217	regulation of blood pressure
GO:0008542	visual learning
GO:0017156	calcium ion-dependent exocytosis
GO:0019229	regulation of vasoconstriction
GO:0030073	insulin secretion
GO:0030252	growth hormone secretion
GO:0034765	regulation of ion transmembrane transport
GO:0042593	glucose homeostasis
GO:0046620	regulation of organ growth
GO:0055085	transmembrane transport
GO:0060083	smooth muscle contraction involved in micturition
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0002095	caveolar macromolecular signaling complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft