Version 5.4
Bos taurus Gene: CDCA8
Summary
InnateDB Gene IDBG-641165.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDCA8
Gene Name borealin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014326
Encoded Proteins
IDBP-693493
borealin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134690:
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108785461-108800524
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019049 ENSBTAP00000019049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000089 mitotic metaphase
GO:0051276 chromosome organization
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0010369 chromocenter
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134690
View Gene Order
ENSMUSG00000028873
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL A4IFM5
UniProt Splice Variant
Entrez Gene 508022
UniGene Bt.27319
RefSeq NM_001083652
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134661 DAAA02009170
GenPept AAI34662
RNA Seq Atlas 508022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca