InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPP1

Summary

InnateDB Gene

IDBG-641200.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPP1

Gene Name

osteopontin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005260

Encoded Proteins

IDBP-693532

osteopontin precursor

IDBP-693536

osteopontin precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21136203

[Homo sapiens] SPP1 exist in secreted and intracellular form; intracellular SPP1, or iSPP1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

PMID 21136203

[Mus musculus] Spp1 exist in secreted and intracellular form; intracellular Spp1, or iSpp1, is involved in cytoskeleton rearrangement and signal transduction downstream of innate immunity receptors (e.g. TLR). iSPP1 may also function as an adaptor or scaffolding protein.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118785:
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:38120578-38127577

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047589	ENSBTAP00000044782
ENSBTAT00000006929	ENSBTAP00000006929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0007155	cell adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030593	neutrophil chemotaxis
GO:0033280	response to vitamin D