InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CRHR1

Summary

InnateDB Gene

IDBG-641310.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRHR1

Gene Name

corticotropin-releasing factor receptor 1 precursor

Synonyms

CRFR1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002749

Encoded Proteins

IDBP-693663

corticotropin-releasing factor receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120088:
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46456088-46483532

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003567

ENSBTAP00000003567

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0030325	adrenal gland development
GO:0042596	fear response
GO:0048149	behavioral response to ethanol
GO:0051458	corticotropin secretion
GO:0051867	general adaptation syndrome, behavioral process
GO:0071376	cellular response to corticotropin-releasing hormone stimulus
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000852	regulation of corticosterone secretion