InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NUDT1

Summary

InnateDB Gene

IDBG-641333.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002480

Encoded Proteins

IDBP-693689

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106268:
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:41522214-41527685

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003218

ENSBTAP00000003218

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0047693	ATP diphosphatase activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006200	ATP catabolic process
GO:0006203	dGTP catabolic process
GO:0006281	DNA repair
GO:0042262	DNA protection
GO:0046061	dATP catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000106268

View Gene Order

ENSMUSG00000036639

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_196618

Phosphate bond hydrolysis by NUDT proteins pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

XM_002698230 XM_002698231 XM_002703156 XM_603849

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas