Version 5.4
Bos taurus Gene: COL8A2
Summary
InnateDB Gene IDBG-641365.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL8A2
Gene Name collagen alpha-2(VIII) chain precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010175
Encoded Proteins
IDBP-693719
collagen, type VIII, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171812:
This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. [provided by RefSeq, Dec 2009]
This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:110299484-110302198
Strand Forward strand
Band
Transcripts
ENSBTAT00000013427 ENSBTAP00000013427
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0048593 camera-type eye morphogenesis
GO:0050673 epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171812
View Gene Order
ENSMUSG00000056174
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.111540
RefSeq NM_001205665 XM_005204813 XM_005204814 XM_005204815 XM_005204816
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca