Version 5.4
Bos taurus Gene: ANGPTL4
Summary
InnateDB Gene IDBG-641435.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPTL4
Gene Name angiopoietin-4 precursor
Synonyms ANGPTL4
Species Bos taurus
Ensembl Gene ENSBTAG00000021811
Encoded Proteins
IDBP-693808
angiopoietin-4 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101280:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:60729756-60773778
Strand Forward strand
Band
Transcripts
ENSBTAT00000029073 ENSBTAP00000029073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0001525 angiogenesis
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0010595 positive regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101280
View Gene Order
ENSMUSG00000027460
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B2Z4B2
UniProt Splice Variant
Entrez Gene 617915
UniGene Bt.29197
RefSeq NM_001076483
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036371 DAAA02036372 EU599227 EU599233
GenPept ACD50903 ACD50909
RNA Seq Atlas 617915

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca