InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.61507

Summary

InnateDB Gene

IDBG-641488.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.61507

Gene Name

myocyte-specific enhancer factor 2B

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001818

Encoded Proteins

IDBP-693857

myocyte enhancer factor 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213999:
The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207. [provided by RefSeq, Mar 2009] This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:4022381-4026425

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002377

ENSBTAP00000002377

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0042826	histone deacetylase binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0030054	cell junction

Orthologs

Species

Mus musculus

Homo sapiens

Gene ID

Gene Order

ENSMUSG00000002345

View Gene Order

ENSG00000213999

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_21402

CDO in myogenesis pathway

REACT_111045

Developmental Biology pathway

REACT_21303

Myogenesis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F2Z4G1

UniProt Splice Variant

Entrez Gene

100271851

UniGene

Bt.61507

RefSeq

NM_001145793

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02019031 JX065116

GenPept

AFN86200

RNA Seq Atlas

100271851