Bos taurus Gene: STRADA | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-641634.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | STRADA | ||||||||||||||||||
Gene Name | STE20-related kinase adapter protein alpha | ||||||||||||||||||
Synonyms | LYK5 | ||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000000056 | ||||||||||||||||||
Encoded Proteins |
STE20-related kinase adapter protein alpha
STE20-related kinase adapter protein alpha
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000266173:
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 19:48628883-48656396 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Insulin receptor signalling cascade pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
mTOR signalling pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
Signal Transduction pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Regulation of AMPK activity via LKB1 pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Regulation of AMPK activity via LKB1 pathway
Signaling by Insulin receptor pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K Cascade pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
PKB-mediated events pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
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KEGG |
mTOR signaling pathway pathway
mTOR signaling pathway pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | A2VE62 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 515024 | ||||||||||||||||||
UniGene | Bt.20073 | ||||||||||||||||||
RefSeq | XM_005220868 NM_001015603 XM_005220864 XM_005220873 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | BC133590 BT020921 DAAA02049321 DAAA02049322 | ||||||||||||||||||
GenPept | AAI33591 AAX08938 | ||||||||||||||||||
RNA Seq Atlas | 515024 | ||||||||||||||||||