InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: XRCC6

Summary

InnateDB Gene

IDBG-641933.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC6

Gene Name

X-ray repair cross-complementing protein 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006103

Encoded Proteins

IDBP-694341

X-ray repair complementing defective repair in Chinese hamster cells 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24098118

[Homo sapiens] Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196419:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:113228164-113251362

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008020

ENSBTAP00000008020

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 200 interaction(s) predicted by orthology.

Predicted by orthology
Total	200 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0032508	DNA duplex unwinding
GO:0033151	V(D)J recombination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050769	positive regulation of neurogenesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex