Bos taurus Gene: BT.63686 | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-641949.3 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | BT.63686 | ||||||||||||||||||||||||
Gene Name | UDP-glucuronosyltransferase 1-6 precursor | ||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000026181 | ||||||||||||||||||||||||
Encoded Proteins |
UDP-glucuronosyltransferase 1-6
UDP-glucuronosyltransferase 1-6
|
||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241635:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 3:113907720-114031371 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | |||||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Heme degradation pathway
Glucuronidation pathway
Metabolism of porphyrins pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
Phase II conjugation pathway
Metabolism pathway
Heme degradation pathway
Glucuronidation pathway
Biological oxidations pathway
Metabolism of porphyrins pathway
|
||||||||||||||||||||||||
KEGG |
Retinol metabolism pathway
Pentose and glucuronate interconversions pathway
Starch and sucrose metabolism pathway
Steroid hormone biosynthesis pathway
Ascorbate and aldarate metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Porphyrin and chlorophyll metabolism pathway
Drug metabolism pathway
Drug metabolism pathway
Retinol metabolism pathway
Ascorbate and aldarate metabolism pathway
Starch and sucrose metabolism pathway
Pentose and glucuronate interconversions pathway
Porphyrin and chlorophyll metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Steroid hormone biosynthesis pathway
Drug metabolism pathway
Drug metabolism pathway
|
||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Bt.15767 Bt.63686 | ||||||||||||||||||||||||
RefSeq | NM_001105636 NM_174762 | ||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||