Version 5.4
Bos taurus Gene: EPS8L1
Summary
InnateDB Gene IDBG-641984.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8L1
Gene Name epidermal growth factor receptor kinase substrate 8-like protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009512
Encoded Proteins
IDBP-694398
EPS8-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131037:
This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:62760766-62773032
Strand Reverse strand
Band
Transcripts
ENSBTAT00000012517 ENSBTAP00000012517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0042608 T cell receptor binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131037
View Gene Order
ENSMUSG00000006154
View Gene Order
Cross-References
SwissProt
TrEMBL E1BKS0
UniProt Splice Variant
Entrez Gene 514504
UniGene Bt.105467
RefSeq NM_001192376
HUGO HGNC:21295
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047756
GenPept
RNA Seq Atlas 514504

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca