Version 5.4
Bos taurus Gene: NARF
Summary
InnateDB Gene IDBG-642039.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NARF
Gene Name nuclear prelamin A recognition factor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018178
Encoded Proteins
IDBP-694497
nuclear prelamin A recognition factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141562:
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50743493-50760548
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024191 ENSBTAP00000024191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005521 lamin binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005638 lamin filament
GO:0031981 nuclear lumen
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000141562
View Gene Order
ENSMUSG00000000056
View Gene Order
Cross-References
SwissProt
TrEMBL F1MEC7
UniProt Splice Variant
Entrez Gene 618340
UniGene
RefSeq XM_005221067
HUGO HGNC:29916
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02049375
GenPept
RNA Seq Atlas 618340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca