Version 5.4
Bos taurus Gene: PAK1
Summary
InnateDB Gene IDBG-642220.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAK1
Gene Name Serine/threonine-protein kinase PAK 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010191
Encoded Proteins
IDBP-694654
Serine/threonine-protein kinase PAK 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149269:
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:18684328-18780241
Strand Forward strand
Band
Transcripts
ENSBTAT00000013448 ENSBTAP00000013448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0006915 apoptotic process
GO:0007015 actin filament organization
GO:0007528 neuromuscular junction development
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0016358 dendrite development
GO:0023014 signal transduction by phosphorylation
GO:0031532 actin cytoskeleton reorganization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0042060 wound healing
GO:0043113 receptor clustering
GO:0043507 positive regulation of JUN kinase activity
GO:0046777 protein autophosphorylation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051496 positive regulation of stress fiber assembly
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030426 growth cone
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000149269
View Gene Order
ENSMUSG00000030774
View Gene Order
Pathways
NETPATH
REACTOME
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_217622
Activation of Rac pathway
REACT_213843
Costimulation by the CD28 family pathway
REACT_225483
CD28 dependent Vav1 pathway pathway
REACT_215526
L1CAM interactions pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_213138
Immune System pathway
REACT_216684
Signal transduction by L1 pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_224780
CD28 co-stimulation pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_206475
Cell-Cell communication pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_249477
Ephrin signaling pathway
REACT_203140
Axon guidance pathway
REACT_207068
DSCAM interactions pathway
REACT_226693
Signaling by VEGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_202074
FCERI mediated MAPK activation pathway
REACT_218413
Generation of second messenger molecules pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
REACT_213465
TCR signaling pathway
REACT_205196
Sema3A PAK dependent Axon repulsion pathway
REACT_203878
Signaling by Robo receptor pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_25299
DSCAM interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
mmu04360
Axon guidance pathway
mmu05211
Renal cell carcinoma pathway
mmu04012
ErbB signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04510
Focal adhesion pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
aurora_a_pathway
Aurora A signaling
cxcr4_pathway
CXCR4-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
s1p_s1p2_pathway
S1P2 pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
rac1_pathway
RAC1 signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
cdc42_pathway
CDC42 signaling events
epha2_fwdpathway
EPHA2 forward signaling
pdgfrbpathway
PDGFR-beta signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.17706
RefSeq NM_001076898
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca