Version 5.4
Bos taurus Gene: LOC788925
Summary
InnateDB Gene IDBG-642221.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOC788925
Gene Name proline-rich protein 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000039784
Encoded Proteins
IDBP-694653
proline-rich protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186654:
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:116021730-116048708
Strand Forward strand
Band
Transcripts
ENSBTAT00000057307 ENSBTAP00000049385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Cellular Component
GO:0031932 TORC2 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000186654
View Gene Order
ENSMUSG00000036106
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL A6H725
UniProt Splice Variant
Entrez Gene 788925
UniGene Bt.102142
RefSeq NM_001101305 XM_005207489
HUGO HGNC:31682
OMIM
CCDS
HPRD
IMGT
EMBL BC146088 DAAA02014916 DAAA02014917 DAAA02014918 DAAA02014919
GenPept AAI46089
RNA Seq Atlas 788925
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca