InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: P4HB

Summary

InnateDB Gene

IDBG-642374.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HB

Gene Name

protein disulfide-isomerase precursor

Synonyms

PDI

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006045

Encoded Proteins

IDBP-694832

protein disulfide-isomerase precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185624:
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51643765-51653754

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007943

ENSBTAP00000007943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006457	protein folding
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0070062	extracellular vesicular exosome