Version 5.4
Bos taurus Gene: DBI
Summary
InnateDB Gene IDBG-642447.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBI
Gene Name Acyl-CoA-binding protein
Synonyms ACBP; EP
Species Bos taurus
Ensembl Gene ENSBTAG00000009517
Encoded Proteins
IDBP-694900
Acyl-CoA-binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155368:
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71561192-71566372
Strand Forward strand
Band
Transcripts
ENSBTAT00000012523 ENSBTAP00000012523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0008289 lipid binding
GO:0036042 long-chain fatty acyl-CoA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001942 hair follicle development
GO:0006641 triglyceride metabolic process
GO:0006810 transport
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0043588 skin development
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000155368
View Gene Order
ENSMUSG00000026385
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03320
PPAR signaling pathway pathway
mmu03320
PPAR signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P07107
TrEMBL
UniProt Splice Variant
Entrez Gene 768330
UniGene Bt.46917
RefSeq NM_001113321
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114181 M15886
GenPept AAA30495 AAI14182
RNA Seq Atlas 768330

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca