InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRIM28

Summary

InnateDB Gene

IDBG-642502.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM28

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006422

Encoded Proteins

IDBP-695030

tripartite motif containing 28

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22995936

[Homo sapiens] TRIM28 interacts with IRF5 and mediates heterochromatinization at M1 macrophage markers (e.g. TNF) to suppress transcription.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130726:
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:65954144-65960263

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008424

ENSBTAP00000008424

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 152 interaction(s) predicted by orthology.

Predicted by orthology
Total	152 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0035851	Krueppel-associated box domain binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070087	chromo shadow domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001837	epithelial to mesenchymal transition
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0016567	protein ubiquitination
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045087	innate immune response
GO:0045739	positive regulation of DNA repair
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0051259	protein oligomerization
GO:0060028	convergent extension involved in axis elongation
GO:0060669	embryonic placenta morphogenesis
GO:1902187	negative regulation of viral release from host cell