InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE6G

Summary

InnateDB Gene

IDBG-642510.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE6G

Gene Name

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000354

Encoded Proteins

IDBP-694964

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185527:
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:51768184-51769908

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000459

ENSBTAP00000000459

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030553	cGMP binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896	response to stimulus