Version 5.4
Bos taurus Gene: BT.61976
Summary
InnateDB Gene IDBG-642561.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.61976
Gene Name v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008938
Encoded Proteins
IDBP-695023
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19667404
[Homo sapiens] SRC and STAT3 play a role in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197122:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:66985878-67004791
Strand Forward strand
Band
Transcripts
ENSBTAT00000011767 ENSBTAP00000011767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 359 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 359 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019904 protein domain specific binding
GO:0020037 heme binding
GO:0042169 SH2 domain binding
GO:0044325 ion channel binding
GO:0046875 ephrin receptor binding
GO:0051219 phosphoprotein binding
GO:0070851 growth factor receptor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030900 forebrain development
GO:0032463 negative regulation of protein homooligomerization
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393 regulation of protein binding
GO:0046777 protein autophosphorylation
GO:0048477 oogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0051902 negative regulation of mitochondrial depolarization
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0070555 response to interleukin-1
GO:0071803 positive regulation of podosome assembly
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197122
View Gene Order
ENSMUSG00000027646
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_115755
Signaling by ERBB2 pathway
REACT_111102
Signal Transduction pathway
REACT_239142
Innate Immune System pathway
REACT_245546
GP1b-IX-V activation signalling pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_229826
Netrin-1 signaling pathway
REACT_227951
Signaling by VEGF pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_224600
c-src mediated regulation of Cx43 function and closure of gap junctions pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_230639
Downstream signal transduction pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_198526
Spry regulation of FGF signaling pathway
REACT_243212
DSCAM interactions pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_239722
Signalling to RAS pathway
REACT_196487
FCGR activation pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_242976
Signaling by EGFR pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204081
CD28 co-stimulation pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_207601
p38MAPK events pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_231290
Signalling to ERKs pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_259068
ADP signalling through P2Y purinoceptor 1 pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_261568
CTLA4 inhibitory signaling pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_206286
GAB1 signalosome pathway
REACT_241951
Ephrin signaling pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_242456
Signaling by FGFR pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
REACT_253341
Netrin mediated repulsion signals pathway
REACT_251507
Signal amplification pathway
REACT_223082
Cell-Cell communication pathway
REACT_214111
Regulation of gap junction activity pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa04370
VEGF signaling pathway pathway
hsa04540
Gap junction pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
mmu04530
Tight junction pathway
mmu04012
ErbB signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04540
Gap junction pathway
mmu04912
GnRH signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
syndecan_2_pathway
Syndecan-2-mediated signaling events
ar_nongenomic_pathway
Nongenotropic Androgen signaling
nfkappabatypicalpathway
Atypical NF-kappaB pathway
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kcipathway
Class I PI3K signaling events
lysophospholipid_pathway
LPA receptor mediated events
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
avb3_integrin_pathway
Integrins in angiogenesis
erbb1_internalization_pathway
Internalization of ErbB1
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
erbb1_downstream_pathway
ErbB1 downstream signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
syndecan_3_pathway
Syndecan-3-mediated signaling events
fgf_pathway
FGF signaling pathway
endothelinpathway
Endothelins
tcptp_pathway
Signaling events mediated by TCPTP
prlsignalingeventspathway
Signaling events mediated by PRL
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
s1p_s1p3_pathway
S1P3 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
cxcr3pathway
CXCR3-mediated signaling events
ar_tf_pathway
Regulation of Androgen receptor activity
epha2_fwdpathway
EPHA2 forward signaling
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_pathway
Arf6 signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.61976
RefSeq NM_001110804 XM_005214807 XM_005214808
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca