Version 5.4
Bos taurus Gene: CHMP2A
Summary
InnateDB Gene IDBG-642570.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP2A
Gene Name charged multivesicular body protein 2a
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013882
Encoded Proteins
IDBP-695033
charged multivesicular body protein 2a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130724:
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:65960799-65963496
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018429 ENSBTAP00000018429
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007034 vacuolar transport
GO:0015031 protein transport
GO:0045184 establishment of protein localization
GO:0050792 regulation of viral process
GO:1902188 positive regulation of viral release from host cell
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130724
View Gene Order
ENSMUSG00000033916
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3T0U5
UniProt Splice Variant
Entrez Gene 523847
UniGene
RefSeq NM_001034550
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102258 DAAA02047921
GenPept AAI02259
RNA Seq Atlas 523847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca