InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MGC157163

Summary

InnateDB Gene

IDBG-642591.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGC157163

Gene Name

RE1-silencing transcription factor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011789

Encoded Proteins

IDBP-695056

hypothetical protein LOC507148

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20798038

[Homo sapiens] RE-1 silencing transcription factor (REST) is part of a repressor complex, along with key components that include histone deacetylase (HDAC) 1 or 2, co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084093:
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:73838854-73863778

Strand

Forward strand

Band

Transcripts

ENSBTAT00000039029

ENSBTAP00000048755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0043065	positive regulation of apoptotic process
GO:0045665	negative regulation of neuron differentiation
GO:0050768	negative regulation of neurogenesis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000084093

View Gene Order

ENSMUSG00000029249

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_202766

Chromatin modifying enzymes pathway

REACT_257106

HDACs deacetylate histones pathway

KEGG

hsa05016

Huntington's disease pathway

mmu05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.112289 Bt.86225

RefSeq

NM_001101880 XM_005207950

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas