InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.24181

Summary

InnateDB Gene

IDBG-642596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.24181

Gene Name

lipopolysaccharide-binding protein precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016864

Encoded Proteins

IDBP-695066

lipopolysaccharide-binding protein precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129988:
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:67874474-67910095

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022428

ENSBTAP00000022428

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0070891	lipoteichoic acid binding

Biological Process

GO:0002232	leukocyte chemotaxis involved in inflammatory response
GO:0002281	macrophage activation involved in immune response
GO:0006953	acute-phase response
GO:0015920	lipopolysaccharide transport
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032490	detection of molecule of bacterial origin
GO:0032496	response to lipopolysaccharide
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043032	positive regulation of macrophage activation
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0060265	positive regulation of respiratory burst involved in inflammatory response
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0090023	positive regulation of neutrophil chemotaxis