Version 5.4
Bos taurus Gene: TSN
Summary
InnateDB Gene IDBG-642616.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSN
Gene Name Translin
Synonyms C3PO
Species Bos taurus
Ensembl Gene ENSBTAG00000006059
Encoded Proteins
IDBP-695092
Translin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000211460:
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73827082-73833492
Strand Forward strand
Band
Transcripts
ENSBTAT00000007959 ENSBTAP00000007959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0008152 metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000211460
View Gene Order
ENSMUSG00000026374
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226022
Gene Expression pathway
REACT_222963
Small interfering RNA (siRNA) biogenesis pathway
REACT_210892
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_201975
Small interfering RNA (siRNA) biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q08DM8
TrEMBL
UniProt Splice Variant
Entrez Gene 509943
UniGene Bt.64624
RefSeq NM_001075422
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123663 BT029902
GenPept AAI23664 ABM06148
RNA Seq Atlas 509943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca