Version 5.4
Bos taurus Gene: BT.39255
Summary
InnateDB Gene IDBG-642660.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.39255
Gene Name DNA topoisomerase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007960
Encoded Proteins
IDBP-695163
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198900:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:70383856-70480307
Strand Forward strand
Band
Transcripts
ENSBTAT00000010466 ENSBTAP00000010466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 110 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003917 DNA topoisomerase type I activity
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0040016 embryonic cleavage
GO:0042493 response to drug
Cellular Component
GO:0000228 nuclear chromosome
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0043204 perikaryon
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198900
View Gene Order
ENSMUSG00000070544
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
Cross-References
SwissProt
TrEMBL F1MN93 Q2HPH0
UniProt Splice Variant
Entrez Gene 534799
UniGene Bt.39255
RefSeq NM_001206487
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY233209 DAAA02036643 DAAA02036644
GenPept AAP69819
RNA Seq Atlas 534799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca