Bos taurus Gene: D2HGDH | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-642692.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | D2HGDH | ||||||||||||
Gene Name | D-2-hydroxyglutarate dehydrogenase, mitochondrial | ||||||||||||
Synonyms | D2HGD | ||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000002847 | ||||||||||||
Encoded Proteins |
D-2-hydroxyglutarate dehydrogenase, mitochondrial
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180902:
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 3:121212557-121237816 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
The citric acid (TCA) cycle and respiratory electron transport pathway
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
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KEGG | |||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
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KEGG | |||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | Bt.62004 | ||||||||||||
RefSeq | NM_001075978 XM_005205040 XM_005205041 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||