Version 5.4
Bos taurus Gene: BT.52974
Summary
InnateDB Gene IDBG-642791.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.52974
Gene Name metalloproteinase inhibitor 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010899
Encoded Proteins
IDBP-695289
metalloproteinase inhibitor 2 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035862:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54079297-54131052
Strand Forward strand
Band
Transcripts
ENSBTAT00000014476 ENSBTAP00000014476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0010951 negative regulation of endopeptidase activity
GO:0030814 regulation of cAMP metabolic process
GO:0043408 regulation of MAPK cascade
GO:0045664 regulation of neuron differentiation
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000035862
View Gene Order
ENSMUSG00000017466
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118682
Activation of Matrix Metalloproteinases pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.111410
RefSeq NM_174472
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca