InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADA

Summary

InnateDB Gene

IDBG-642808.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADA

Gene Name

adenosine deaminase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005280

Encoded Proteins

IDBP-695310

adenosine deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196839:
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:73750479-73773983

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006947

ENSBTAP00000006947

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019239	deaminase activity

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001890	placenta development
GO:0002314	germinal center B cell differentiation
GO:0002636	positive regulation of germinal center formation
GO:0002686	negative regulation of leukocyte migration
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006154	adenosine catabolic process
GO:0006157	deoxyadenosine catabolic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0010460	positive regulation of heart rate
GO:0030324	lung development
GO:0030890	positive regulation of B cell proliferation
GO:0032261	purine nucleotide salvage
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0042110	T cell activation
GO:0043066	negative regulation of apoptotic process
GO:0045580	regulation of T cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045987	positive regulation of smooth muscle contraction
GO:0046061	dATP catabolic process
GO:0046101	hypoxanthine biosynthetic process
GO:0046103	inosine biosynthetic process
GO:0046111	xanthine biosynthetic process
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0048286	lung alveolus development
GO:0048541	Peyer's patch development
GO:0048566	embryonic digestive tract development
GO:0050728	negative regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0060169	negative regulation of adenosine receptor signaling pathway
GO:0060407	negative regulation of penile erection
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070256	negative regulation of mucus secretion